Northwestern Events Calendar


M-I Dept. Virtual Seminar - Why Does HCMV Encode A Glycoprotein H Complex That Lacks Glycoprotein L?

When: Tuesday, October 27, 2020
12:00 PM - 1:00 PM  

Where: Online
Webcast Link

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Richard Longnecker   312.503.0467

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: "Why Does HCMV Encode A Glycoprotein H Complex That Lacks Glycoprotein L?"

Speaker: Jeremy Kamil, PhD / LSU Health, Shreveport

Host: Richard Longnecker, PhD


In many enveloped viruses, a single glycoprotein suffices to bind host receptors and fuse membranes to initiate infection.  Herpesviruses, however, encode a large number of glycoproteins, several of which play roles in immune evasion and never leave the endoplasmic reticulum, while other glycoproteins, comprised of or built upon glycoprotein H (gH)/ glycoprotein L (gL) heterodimers, bind receptors to regulate membrane fusion events which are catalyzed by glycoprotein B, the proximal fusogen for all herpesviruses.  Human cytomegalovirus (HCMV), the so called “prototype” betaherpesvirus, encodes at least three glycoprotein H complexes, one of which, gH/UL116, lacks the canonical gH dimerization partner, gL.  I will share results that suggest a function for this complex.

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Meeting ID: 914 2348 9708
Passcode: 344234


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