Description:

Title:

Ribosome Hibernation: What, How and Why

Speaker: Mee-Ngan Frances Yap, PhD / Northwestern University

Host: Laimonis Laimins, PhD

Topic:

The formation of translationally silent ribosomes is a universal hallmark of both bacteria and eukaryotes that is linked to cell survival. Ribosome hibernation is believed to serves as a reservoir that, when conditions become favorable, allows the hibernating ribosomes to be recycled for new rounds of translation. Most bacteria inactivate ribosomes by dimerizing 70S ribosomes to form the hibernating 100S complex. This presentation will discuss the mechanism of 70S dimerization and the diverse roles of ribosome hibernation that have emerged from our recent structural, biochemical and genetic studies in a methicillin-resistant Staphylococcus aureus (MRSA).