Northwestern Events Calendar

Feb
8
2021

Biostatistics & Statistics Joint Seminar Series

When: Monday, February 8, 2021
4:00 PM - 5:00 PM CT

Where: Online

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Lucia Ontiveros  

Group: Department of Preventive Medicine- Division of Biostatistics

Category: Lectures & Meetings

Description:

Douglas D. Gunzler, PhD

Case Western Reserve University, Population Health Research Institute, Center for Health Care Research & Policy, MetroHealth Medical Center, Cleveland, Ohio

Presentation Title:

An Introduction to Structural Equation Modeling for Analysis of Overlapping Symptoms in Co-occurring Conditions

Abstract:

Structural Equation Modeling (SEM) is a very general multivariate technique that can be used for analyzing data in the presence of measurement error and complex causal relationships. In this seminar, we describe SEM for health and medical research. The discussion is motivated by a problem of symptom overlap routinely faced by clinicians and researchers, in which symptoms or test results are common to two or more co-occurring conditions. As a result of such overlap, diagnoses, treatment decisions and inferences about the effectiveness of treatments for these conditions can be biased. This problem is further complicated by increasing reliance on patient-reported outcomes, which introduces systematic error based on an individual’s interpretation of a test questionnaire. SEM provides flexibility in correcting for this type of measurement bias and disentangling the overlap. Scales and scoring approaches can be revised to account for this overlap, leading to better care. We discuss an example of depression screening in multiple sclerosis patients in which depressive symptoms overlap with other symptoms, such as fatigue, cognitive impairment and functional impairment.

 

For Zoom link please contact Lucia Ontiveros : lucia.ontiveros@northwestern.edu

 

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