Northwestern Events Calendar

Mar
5
2021

Mesolimbic cholinergic and dopaminergic mechanisms mediating substance use and mood disorder phenotypes

When: Friday, March 5, 2021
12:00 PM - 1:00 PM Central

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings

Description:

Abstract

The Department of Physiology welcomes Dr. Nii Addy with Yale School of Medicine.

Dr. Addy’s research focuses on the neurobiological processes underlying substance use disorders, mood disorders, and comorbid substance use and mood disorders. Dr. Addy’s team uses multiple methodologies, including behavioral paradigms such as intravenous drug self-administration, acute and chronic stress paradigms, and anxiety and amotivation paradigms, along with integrated pharmacological, in vivo electrochemical, and in vivo optogenetic methods to investigate these mechanisms. Dr. Addy will present his preclinical findings, revealing cholinergic and L-type calcium channel processes in the mesolimbic system that robustly mediate substance use and mood disorder behavioral phenotypes through regulation of dopaminergic activity. Dr. Addy will also describe ongoing work with potential therapeutic compounds, targeting subtype-specific muscarinic receptors and L-type calcium channels. Finally, he will describe upcoming clinical collaborative studies, based on his team’s recent preclinical findings.  

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