Description:

Viral Hijacking of Host Motor Proteins to Promote Nuclear Entry

Speaker - Chelsey Spriggs,PhD

Postdoctoral Fellow, Department of Cell and Developmental Biology, University of Michigan Medical School, Tsai Lab

During entry, most DNA viruses must navigate the crowded cellular environment to reach the nucleus where transcription and replication of the viral genome occur. How polyomavirus (PyV), a small, DNA tumor virus, accomplishes this essential step in infection is unclear. Here, I will describe an unexpected and novel role for host motor proteins in this process and the next big questions in the field.