Northwestern Events Calendar

Apr
14
2021

Statistics Seminar Series (joint with Biostatistics): Hyunseung Kang “Assumption-Lean Analysis of Cluster Randomized Trials in Infectious Diseases”

When: Wednesday, April 14, 2021
11:00 AM - 12:00 PM Central

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Kisa Kowal   847.491.3974

Group: Department of Statistics

Category: Academic, Lectures & Meetings

Description:

Department of Statistics 2020-2021 Seminar Series (joint with Biostatistics) - Spring 2021

“Assumption-Lean Analysis of Cluster Randomized Trials in Infectious Diseases”

Hyunseung Kang, Assistant Professor, Department of Statistics, University of Wisconsin-Madison

Abstract
Cluster randomized trials (CRTs) are a popular design to study the effect of interventions in infectious disease settings. However, standard analysis of CRTs primarily relies on strong parametric methods, usually a Normal mixed effect models to account for the clustering structure, and focus on the overall intent-to-treat (ITT) effect to evaluate effectiveness. The paper presents two methods to analyze two types of effects in CRTs, the overall and heterogeneous ITT effects and the spillover effect among never-takers who cannot or refuse to take the intervention. For the ITT effects, we make a modest extension of an existing method where we do not impose parametric models or asymptotic restrictions on cluster size. For the spillover effect among never-takers, we propose a new bound-based method that uses pre-treatment covariates, classification algorithms, and a linear program to obtain sharp bounds. A key feature of our method is that the bounds can become dramatically narrower as the classification algorithm improves and the method may also be useful for studies of partial identification with instrumental variables. We conclude by reanalyzing a CRT studying the effect of face masks and hand sanitizers on transmission of 2008 interpandemic influenza in Hong Kong. This is joint work with Chan Park (UW-Madison).

 

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