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CDB Seminar Series Presents: "Folding tissues across length scales: cell-based origami," Adam C. Martin, Ph.D., Massachusetts Institute of Technology, Cambridge, MA

Headshot of Dr. Adam C. Martin, Ph.D.

When: Wednesday, June 8, 2022
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, SQBRC 1-230, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Sarah Alber   (312) 503-7958

Group: Department of Cell and Developmental Biology

Category: Lectures & Meetings



"Folding tissues across length scales: cell-based origami"

Adam C. Martin, Ph.D.
Associate Professor of Biology
Department of Biology
Massachusetts Institute of Technology, Cambridge, MA


Wednesday, June 8, 2022

12:00-1:00 PM

Location: Simpson Querrey Auditorium, SQBRC 1-230

Throughout the lifespan of an organism, tissues are remodeled to shape organs and organisms and to maintain tissue integrity and homeostasis.  Apical constriction is a ubiquitous cell shape change of epithelial tissues that promotes epithelia folding and cell/tissue invagination in a variety of contexts.  Apical constriction promotes tissue bending by changing the shape of constituent cells from a columnar-shape to a wedge-shape. Drosophila gastrulation is one of the classic examples of apical constriction, where cells constrict to fold the primitive epithelial sheet and internalize cells that will give rise to internal organs.  We have used a combination of imaging, experimental perturbation, and modeling, to determine how actomyosin organization promotes tissue folding.  The actin cytoskeleton is organized in both time and space to facilitate apical constriction.  We found that actomyosin contraction is pulsatile and requires dynamic regulation of upstream signaling processes.  In addition, we found that transitions in the mode of actomyosin contractility are associated with dramatic changes in tissue movements.  Furthermore, we discovered that differential patterning of actin and myosin across tissues, can lead to regionalized cell behaviors that promote proper shape formation.  Overall, our findings have advanced the field’s understanding of how tissue shape emerges from actomyosin patterning across different length scales.

Host: Dr. Luisa Iruela-Arispe
Stephen Walter Ronson Professor and Chair
Department of Cell and Developmental Biology  

For more information please contact
To subcribe to the CDB Seminar Series listserve please visit

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