When:
Thursday, April 21, 2022
10:00 AM - 11:00 AM CT
Where: Simpson Querrey Biomedical Research Center, Simpson Querry Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Beverly Kirk
(312) 503-5217
Group: Biochemistry & Molecular Genetics Seminar Series
Category: Academic
The Department of Biochemistry and Molecular Genetics presents:
Martin Kampmann, PhD, Associate Professor, Department of Biochemistry & Biophysics, Univeristy of California, San Francisco
Title: Uncovering cellular mechanisms of brain disease by CRISPR-based functional genomics
Abstract: The Kampmann lab develops functional genomics technologies to understand cellular and molecular mechanisms of human brain disease, and to discover new therapeutic strategies. Our CRISPR-based functional genomics platform in human iPSC-derived neurons and glia enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. Using this approach, we uncovered a neuron-specific pathway linking lysosomal dysfunction to ferroptosis and mechanisms regulating disease-associated states of astrocytes and microglia. We are characterizing how cellular functions are altered in disease states of brain cells, and identify mechanisms underlying cell type-specific vulnerability.