Description:

The Basic Research Seminar Series of the Robert H. Lurie Comprehensive Cancer of Northwestern University presents:

FOXA1 Pioneer Factor in Cancer Biology and Immunology

Haojie Huang, PhD
Gordon H. and Violet Bartels Professor of Cellular Biology
Professor of Biochemistry and Molecular Biology and Urology
Director of Urology Basic Sciences Research
Mayo Clinic College of Medicine and Science

The transcription factor FOXA1 regulates expression of genes involved in signaling and cancer immune responses. Dr. Huang’s group has shown that overexpression of FOXA1 in prostate, breast, and bladder cancer promotes immuno- and chemotherapy resistance in mice and humans. FOXA1 overexpression could be a prognostic factor to predict therapy resistance and a viable target to sensitize luminal prostate, breast, and bladder cancer to immuno- and chemotherapy.

The Basic Research Seminar series presents prominent basic science speakers weekly to inspire and promote ongoing cancer research at Northwestern University.