Northwestern Events Calendar

Apr
26
2022

M-I Dept. Seminar Series - "Interferon-Mediated Regulation of T Cell Function and Immunotherapy in Cancer and Chronic Infection"

When: Tuesday, April 26, 2022
12:00 PM - 1:00 PM Central

Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: "Interferon-Mediated Regulation of T Cell Function and Immunotherapy in Cancer and Chronic Infection"

David Brooks, PhD

Senior Scientist, Tumor Immunotherapy Program, Princess Margaret Cancer Center

Professor, Department of Immunology, University of Toronto

 

Faculty Host: Pablo Penaloza-MacMaster

Topic:

Abstract: Type I interferons (IFN-Is) are emerging as key drivers of both inflammation and immunosuppression in chronic infections and cancer. Similarly IFN-Is are central regulators of responses to immunotherapy, but also drive the feedback inhibition underlying therapeutic resistance. Yet, the mechanistic basis underlying the cellular switch from beneficial to detrimental IFN-I induced effects is unknown. In this seminar, I will discuss our new research identifying how IFN-Is simultaneously positively and negatively regulate anti-viral and anti-tumor immunity, determine responses to immunotherapy, and ultimately can be used to predict the efficacy of anti-PD1-based therapy.

 

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