When:
Tuesday, April 26, 2022
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: "Interferon-Mediated Regulation of T Cell Function and Immunotherapy in Cancer and Chronic Infection"
David Brooks, PhD
Senior Scientist, Tumor Immunotherapy Program, Princess Margaret Cancer Center
Professor, Department of Immunology, University of Toronto
Faculty Host: Pablo Penaloza-MacMaster
Topic:
Abstract: Type I interferons (IFN-Is) are emerging as key drivers of both inflammation and immunosuppression in chronic infections and cancer. Similarly IFN-Is are central regulators of responses to immunotherapy, but also drive the feedback inhibition underlying therapeutic resistance. Yet, the mechanistic basis underlying the cellular switch from beneficial to detrimental IFN-I induced effects is unknown. In this seminar, I will discuss our new research identifying how IFN-Is simultaneously positively and negatively regulate anti-viral and anti-tumor immunity, determine responses to immunotherapy, and ultimately can be used to predict the efficacy of anti-PD1-based therapy.