Northwestern Events Calendar

May
24
2022

M-I Dept. Seminar Series - "An Alphaherpesvirus Structural Protein Regulates the Kinesin Motor to Drive Invasion of the Nervous System"

When: Tuesday, May 24, 2022
12:00 PM - 1:00 PM Central

Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: 

"An Alphaherpesvirus Structural Protein Regulates the Kinesin Motor to Drive Invasion of the Nervous System"

Dongho Kim, Graduate Student, Lab of Gregory A. Smith, PhD

Faculty Host: Gregory A. Smith, PhD

Topic:

Brief summary: Neurotropic alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), recruit microtubule-associated motor proteins to invade the nervous system. The incoming viral particle captures the dynein-dynactin complex for sustained retrograde axonal transport to the centrosome in the neural soma. Our lab recently reported that HSV-1 captures kinesin-1 from epithelial cells, carries the motor between cells as a viral structural component, and subsequently uses the motor to transport from the centrosome to the nucleus in neurons. We refer to this repurposing of a cellular protein as a proviral component of the virion architecture as assimilation. During this presentation, I will present data indicating that the incoming viral particle suppresses assimilated kinesin activity during dynein-mediated retrograde axonal transport and discuss how removal of this suppression at the centrosome may be key to redirect capsids to the nucleus and complete the neuroinvasive program.

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