Description:

Online and In-Person Event

Abstract

16p11.2 duplication confers strong risk to schizophrenia. We set out to isolate changes in neuronal development that may result in cortical dysfunction in schizophrenia. Multi-electrode array reveals strong deficits in electrical and network activity resulting from 16p11.2 duplication, validated in patient and CRISPR-cas9 modified iPSC-derived neurons. Transcriptomics, morphological analysis and calcium network imaging reveal robust alterations in neuronal function. These results support profound neuronal deficits that may contribute to schizophrenia risk in 16p11.2 duplication patients.

About NU-HTA

The High Throughput Analysis Core (NU-HTA) is a shared, open-access resource that provides equipment and expertise for the development and execution of high throughput biological analysis and screening. The facility is fully equipped with state-of-the-art liquid handling and microplate detection instrumentation.

The Event will take place in person at:

Northwestern Feinberg School of Medicine

Robert H Lurie Medical Research Center

Searle Seminar Room (1-161)

Online via Zoom:  (REGISTRATION REQUIRED)

Light snacks will be served.