Northwestern Events Calendar

Nov
2
2021

Translational Research in Solid Tumors (TRIST) Seminar: Precision Nanotherapeutics for Treatment of Glioblastoma

Alexander H. Stegh, PhD

When: Tuesday, November 2, 2021
11:00 AM - 12:00 PM CT

Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Cost: free

Contact: Jodi Johnson  

Group: Lurie Cancer Center Clinical Sciences Research Programs

Category: Lectures & Meetings

Description:

The Translational Research in Solid Tumors (TRIST) Program presents:

Precision Nanotherapeutics for Treatment of Glioblastoma

Alexander H. Stegh, PhD
Associate Professor of Neurology (Neuro-oncology) and Medicine
The Ken & Ruth Davee Department of Neurology
Feinberg School of Medicine

The
Stegh lab, in collaboration with Dr Chad Mirkin, developed a novel
precision medicine approach for glioblastoma ( treatment involving
brain penetrant spherical nucleic acids ( conjugated with gene
regulatory siRNA or immunostimulatory DNA oligonucleotides SNAs are
modular nanostructures, composed of densely functionalized and highly
oriented nucleic acids that are spherically presented around a nanoparticle
core This unique 3 D architecture leads to biochemical and biological
properties that are radically different from linear oligonucleotides,
including delivery and privileged access to intracranial tumor sites upon
systemic administration Dr Stegh will review preclinical data that establish
SNAs as a potent gene regulatory platform that, upon IV administration,
downregulates oncogene expression in intracranial GBM Results from a
single arm, open label phase 0 first in human trial NCT 03020017 to
determine safety, pharmacokinetics, intratumoral accumulation and gene
suppressive activity of SNAs with gold nanoparticle cores, carrying siRNA
specific for the GBM oncogene Bcl 2 Like 12 will be presented The
presentation will conclude with an outlook on development of novel
immuno stimulatory SNA based therapies, including SNA architectures that
activate cGAS STING innate immunity.

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