When:
Tuesday, November 23, 2021
12:15 PM - 1:30 PM CT
Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title:
Antigen Persistence Leads to Unique Differentiation of Mycobacterial Lpid Antigen-Specific T Cells
Speaker: Eva Morgun, Graduate Student, DGP, Lab of Dr. Chung-Ru Wang
Faculty Host: Chung-Ru Wang, PhD
Topic:
Tuberculosis remains a serious global epidemic and with the rise of multi-drug resistant strains, an efficacious vaccine solution is imperative. We have created a nanoparticle (NP) vaccine containing mycolic acid (MA), a key lipid antigen found in Mycobacterium tuberculosis. We found that MA-NP vaccination leads to a persistent depot of MA in alveolar macrophages that is able to activate MA-specific T cells 6 weeks post-vaccination. Furthermore, in this environment, MA-specific T cells acquire a T follicular-like phenotype. Antigen archiving and the associated T cell phenotype may have important implications for the efficacy and development of lipid vaccines.