Northwestern Events Calendar

Jan
10
2022

Pharmacology Research Works in Progress: Emily Pinheiro and Emily Stroup

When: Monday, January 10, 2022
4:00 PM - 5:00 PM Central

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lexi Smith   (312) 503-4893

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

Emily Pinheiro
MD/PhD Candidate in the Laboratory of Paul Burridge, PhD

"A Patient-Specific Model of Nilotinib-Induced Vascular Disease”

Nilotinib is a highly effective tyrosine kinase inhibitor used to treat Chronic Myeloid Leukemia (CML). While nilotinib successfully treats CML, a common and serious side effect is development of vascular disease (NVD) even in patients without pre-existing risk factors. To date, the mechanisms of NVD are unknown and no tools currently exist to predict which patients will develop NVD. We hypothesize that patient-specific human induced pluripotent stem cell derived vascular cell types can be used to model NVD in vitro, recapitulate patient-specific NVD susceptibility, and determine the underlying mechanisms of NVD.

Emily Stroup
PhD Candidate in the Laboratory of Ji Zhe, PhD

"Deep Learning Models of Polyadenylation"

Alternative polyadenylation (APA) is tightly coordinated with both transcription and splicing mechanisms to regulate transcription termination and 3'-end formation. Few studies have taken an unbiased approach to analyzing the regulation of APA, and there remain several shortcomings with current research even though APA has been implicated in proliferation, development, and cancer. We aim to examine the regulation, evolution, and functionality of polyadenylation sites across the genome in both health and disease by leveraging a novel, interpretable deep learning architecture. This model can also be applied to many open questions in genetics to provide insight into the biology underlying these complex phenomena.

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