Northwestern Events Calendar

Jan
31
2023

M-I Dept. Seminar Series / Mechanisms of MARTX Toxin Binding to Mammalian Host Surfaces  

When: Tuesday, January 31, 2023
12:00 PM - 1:00 PM Central

Where: Simpson Querrey Biomedical Research Center, SQBRC Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

 

Title: Mechanisms of MARTX Toxin Binding to Mammalian Host Surfaces  

Speaker: Jiexi Chen, DGP Graduate Student, Lab of Karla Satchell

Topic:

Multifunctional-autoprocessing repeats-in-toxin (MARTX) toxins are large pore-forming toxins secreted from several Gram-negative bacteria. Importantly, it is the dominant virulence factor of the highly lethal Vibrio vulnificus, a foodborne marine pathogen. To study the previously unknown mechanism of how MARTX toxin interacts with host at cellular surface, we purified multiple fragments of the toxin and tested their binding ability to host cells. We found two N-terminal fragments of the toxin independently attach to mammalian cell membrane via host N-glycans and heparan sulfate.This study unravels novel mechanisms of toxin-host interactions at host surfaces with implications for Vibrio vulnificus pathogenesis.  

Host:  Karla Satchell, PhD, Professor, Dept. of Microbiology-Immunology

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