Northwestern Events Calendar

Jun
16
2023

Neuroscience Seminar Series: Christoph Kellendonk Ph.D "Using human brain imaging studies as a guide towards animal models for schizophrenia"

When: Friday, June 16, 2023
12:00 PM - 1:00 PM Central

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Emily Larsen   (312) 503-1687

Group: Department of Neuroscience Seminars

Category: Lectures & Meetings

Description:

The Kellendonk laboratory uses mouse genetic tools in an effort to understand the biology that underlies cognitive and negative symptoms of schizophrenia. Schizophrenia is characterized by three symptom clusters: the cognitive, negative and positive symptoms. While the positive symptoms – which include disordered thought processes, hallucinations and delusions – are the most characteristic feature of the disorder, such symptoms are more difficult to model in the mouse. In contrast, cognitive and negative symptoms of the disorder – including deficits in working memory and motivation – have behavioral readouts in mice that are more homologous to humans. Cognitive and negative symptoms are poorly understood, difficult to treat and their severities are a better predictor for the long-term prognosis of patients than the degree of positive symptoms.

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