Northwestern Events Calendar


M-I Seminar Series / Role of TIM Family of Genes in Regulating Anti-Tumor Immunity

When: Tuesday, February 28, 2023
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings



Role of TIM Family of Genes in Regulating Anti-Tumor Immunity


Vijay Kuchroo, Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston




T cell Immunoglobulin and Mucin containing molecules 3 (Tim-3), first identified as a molecule expressed on IFN-g producing T cells, is emerging as an important immune-checkpoint molecule whose therapeutic blockade is currently being investigated in multiple human malignancies. While expression of Tim-3 on CD8+ T cells in the tumor microenvironment is considered a cardinal sign of terminal T cell dysfunction, Tim-3 is also expressed on several other immune cells, confounding the interpretation of immunological and clinical results following blockade using anti-Tim-3 monoclonal antibodies.  Using conditional knockouts of Tim-3 together with single-cell RNA-seq, we demonstrate the singular importance of Tim-3 expression in dendritic cells (DCs), whereby loss of Tim-3 on DCs, promotes strong anti-tumor immunity by regulating Inflammasome activation. Another family member Tim-1 has been found to be expressed on a subset of B cells that expand during tumor growth. Selective deletion of Havcr1 (the gene encoding TIM-1) in B cells both dramatically inhibited tumor growth and enhanced effector T cell responses.  Our results demonstrate that besides T cells, TIM -family of proteins may be checkpoint molecules on other cell types as well and manipulation of the Tim-3 and Tim-1 enables the engagement of DCs and B cells to promote anti-tumor immunity and inhibit tumor growth.”



Pablo Penaloza-MacMaster, PhD, Assistant Professor, Dept. Of Microbiology-Immunology



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