When:
Friday, January 27, 2023
11:00 AM - 12:00 PM CT
Where:
Online
Webcast Link
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Melissa Daley
Group: Department of Pharmacology Seminars
Category: Lectures & Meetings
"Dissecti ng the multi -dimensional cancer-hostcrosstalk during tumorprogression"
Meeting ID: 931 0082 2838
Abstract:
Cancer-host interactions are constantly evolving dependent on location, timing, local tumor ecosystem, and systemic host factors. For instance, the first foothold of disseminated tumor cells in the bone marrow is adjacent to blood vessels. The interaction with endothelium causes “dormancy”. However, bone turnover triggers a relocation of cancer cells to where new bone is being generated. There, cancer cells increase phenotypic plasticity and acquire the ability to further metastasize. Another example is the distant, pre-metastatic communication between solid tumors and bone marrow. Some tumors can remotely induce skewed myelopoiesis. The accumulation of aberrant myeloid cells drives systemic immunosuppression and neutrophil-shuffling between tumor and blood, both processes promoting metastasis. Together, our previous and ongoing work highlights the multifaceted nature of tumor-host crosstalk, and prompted the application of more systematic approaches in future studies.
Xiang "Shawn" Zhang, PhD
Interim Director, Lester and Sue Smith Breast Cancer Center
Professor of Molecular and Cellular Biology
Baylor College of Medicine