Northwestern Events Calendar

Jan
27
2023

Lurie Cancer Center and Pharmacology Department Faculty Candidate Seminar: Xiang Zhang PhD

When: Friday, January 27, 2023
11:00 AM - 12:00 PM Central

Where: Online
Webcast Link

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Melissa Daley  

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

"Dissecti ng the multi -dimensional cancer-hostcrosstalk during tumorprogression"

Join Zoom Meeting

Meeting ID:  931 0082 2838

 

Abstract:
Cancer-host interactions are constantly evolving dependent on location, timing, local tumor ecosystem, and systemic host factors. For instance, the first foothold of disseminated tumor cells in the bone marrow is adjacent to blood vessels. The interaction with endothelium causes “dormancy”. However, bone turnover triggers a relocation of cancer cells to where new bone is being generated. There, cancer cells increase phenotypic plasticity and acquire the ability to further metastasize. Another example is the distant, pre-metastatic communication between solid tumors and bone marrow. Some tumors can remotely induce skewed myelopoiesis. The accumulation of aberrant myeloid cells drives systemic immunosuppression and neutrophil-shuffling between tumor and blood, both processes promoting metastasis. Together, our previous and ongoing work highlights the multifaceted nature of tumor-host crosstalk, and prompted the application of more systematic approaches in future studies.

 

Xiang "Shawn" Zhang, PhD

Interim Director, Lester and Sue Smith Breast Cancer Center

Professor of Molecular and Cellular Biology

Baylor College of Medicine

 

 

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