Northwestern Events Calendar


M-I Dept. Seminar / SAMD9-Mediated Innate Immunity Against Viruses and Myeloid Tumors

When: Tuesday, October 24, 2023
10:00 AM - 11:00 AM CT

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: SAMD9-Mediated Innate Immunity Against Viruses and Myeloid Tumors


Yan Xiang, Ph.D., Professor, Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio


SAMD9 and SAMD9L (SAMD9/9L) are a pair of human genes that play an important role in innate immunity against viruses and myeloid tumors. Mutations in human SAMD9/9L, that display gain-of-function (GoF) phenotypes, are associated with multisystem developmental disorders characterized by immunodeficiency and a predisposition to myelodysplastic syndromes (MDS) and leukemia. SAMD9/9L are particularly potent in restricting poxvirus replication, and poxviruses have evolved multiple specific inhibitors against these genes. Recently, our lab made a significant discovery that SAMD9 is a poxvirus-activable tRNA endonuclease that specifically cleaves phenylalanine tRNA, revealing tRNA-Phe depletion as an antiviral mechanism and a pathogenic condition in SAMD9/9L disorders. Studies of SAMD9/9L and their viral inhibitors are crucial for understanding poxvirus host tropisms and for developing therapeutic strategies for diseases caused by GoF SAMD9/9L mutations.


Host: Derek Walsh, PhD, Professor, Department of Microbiology-Immunology

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