Northwestern Events Calendar


M-I Dept. Seminar / Host Polymerases Contribute to Human Cytomegalovirus Genome Stability

When: Tuesday, November 7, 2023
10:00 AM - 11:00 AM CT

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: Host Polymerases Contribute to Human Cytomegalovirus Genome Stability


Felicia Goodrum, PhD, Professor, The University of Arizona School of Medicine


Like all herpesviruses, human cytomegalovirus (HCMV), encodes its own DNA polymerase and processivity facto for synthesis of its genome. However, how does HCMV can synthesize it large and complex dsDNA genome with a single polymerase when human cells require 14 polymerases? It turns out that HCMV is using host polymerases! We have been working to understand the mechanisms by which it recruits and modulates host polymerases and their impact on viral replication and genome integrity.

Host: Mojgan Naghavi, PhD, Professor, Dept. of Microbiology-Immunology

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