Description:

Title: Pathogenesis and Dynamics of Klebsiella pneumoniae Bacteremia

Speaker: Michael Bachman, MD, PhD,

Director, Clinical Microbiology Laboratory; Associate Professor of Pathology and Microbiology and Immunology, University of Michigan

Topic: Klebsiella pneumoniae is a leading cause of bacteremia, in which the pathogen progresses from initial site infection to dissemination and finally survival in the blood and blood-filtering organs. We have identified fitness genes important in each phase of infection and demonstrated their conservation and importance for bacteremia in related Gram-negative pathogens. We have also begun to uncover the dynamics of founding populations, bottlenecks and population expansion that occur in Klebsiella bacteremia and how they are altered by fitness mutants. 

Host: Alan Hauser, MD, PhD, Associate Professor, Department of Microbiology-Immunology