Description:

Title: Evolutionary Trajectories and Genomic Mechanisms of Antibiotic Resistance

Speaker: Anupama Khare, PhD,  NIH Stadtman Investigator, Laboratory of Molecular Biology. NCI/CCR

Topic:

Antibiotics with multiple cellular targets can theoretically reduce the frequency of resistance evolution, but mechanisms of resistance against such antibiotics are understudied. We show that genomic amplifications of efflux pumps can lead to the evolution of resistance against dual-targeting antibiotics, circumventing the requirement for multiple mutations in the cell. Such amplifications can lead to cross-resistance and hetero-resistance, and provide alternate high-frequency evolutionary paths to antibiotic resistance.

Host: M.-N. Frances Yap, Associate Professor, Dept. of Microbiology-Immunology