When:
Tuesday, January 9, 2024
10:00 AM - 11:00 AM CT
Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology
Category: Lectures & Meetings
Title: Evolutionary Trajectories and Genomic Mechanisms of Antibiotic Resistance
Speaker: Anupama Khare, PhD, NIH Stadtman Investigator, Laboratory of Molecular Biology. NCI/CCR
Topic:
Antibiotics with multiple cellular targets can theoretically reduce the frequency of resistance evolution, but mechanisms of resistance against such antibiotics are understudied. We show that genomic amplifications of efflux pumps can lead to the evolution of resistance against dual-targeting antibiotics, circumventing the requirement for multiple mutations in the cell. Such amplifications can lead to cross-resistance and hetero-resistance, and provide alternate high-frequency evolutionary paths to antibiotic resistance.
Host: M.-N. Frances Yap, Associate Professor, Dept. of Microbiology-Immunology