When:
Tuesday, February 20, 2024
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title:
Calcium, Manganese or a Membrane: Which Are the Key Drivers of Type 2 Secretion System Fibre Assembly and Function?
Speaker: Jenny-Lee Thomassin, Assistant Professor, University of Biochemistry, Microbiology and Immunology
University of Saskatchewan, Saskatoon, SK CANADA
Topic:
The bacterial type 2 secretion system (T2SS) is used by Gram negative bacteria to transport a wide range of seemingly unrelated proteins from the periplasm to the external environment. The T2SS assembles a central periplasmic fibre. Dynamic fibre assembly is required for active protein transport, although the mechanism remains unclear. We previously demonstrated that fibre assembly and stability is calcium dependent. However, the role of calcium in protein secretion, the main function of the T2SS was never determined. In this talk, I will explore how calcium, manganese, and the cytoplasmic membrane impact fibre assembly, and protein secretion.
Host:
Bacteriology Gaduate Students and Postdocs, Coordinating Host, Selma Metaane, PhD, Lab of Hank Seifert, Dept. of Microbiology-Immunology