Description:

Title:

Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions 

Speaker:

Tim van Opijnen, Ph.D 

Boston Children’s Hospital

Division of Infectious Diseases

Associate Professor of Pediatrics

Harvard Medical School

Broad Institute of MIT

Topic:

Although vaccines and antibiotics have been historically successful in combating bacterial infections, limited vaccine coverage and the rise of antibiotic resistance emphasize the need to design new targeted treatment strategies. In an attempt to answer this call, we are developing platform technology that combines data from approaches including single cell, bulk and dualRNA-Seq, Tn-Seq, and CRISPRi into multidimensional bacterial profiles, that can be computationally mined to aid in developing drug and/or immune-enhancing approaches. 

Host:

Bacteriology Graduate Students and Postdocs, coordinated by Graduate Student Marine LeBrun