Northwestern Events Calendar


BMG Seminar: Kai Tan, PhD, University of Pennsylvania

When: Thursday, February 22, 2024
10:00 AM - 11:00 AM CT

Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Linda Mekhitarian Jackson   (312) 503-5229

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings


The Department of Biochemistry & Molecular Genetics presents:

Kai Tan, PhD
Richard & Sheila Sanford Professor
Departments of Pediatrics, Cell & Dev Biology, Genetics
Director, Center for Single Cell Biology
Children’s Hospital of Philadelphia
Perelman School of Medicine
University of Pennsylvania


"Progenitor cells in therapy resistance of high-risk leukemias"


The role of leukemic initiating cells as a therapy-resistant population in myeloid leukemia is well established. However, the existence and molecular signatures of stem/progenitor-like blasts in acute lymphoblastic leukemia have not been studied extensively. I will  discuss the identification, characterization, targeting of a pan-leukemia HSPC-like blast population associated with chemotherapy resistance and unfavorable patient outcome, using integrative analysis of single-cell multiomics, bulk RNA-Seq and clinical data.

Host: Dr Ruli Gao, Assistant Professor of Biochemistry and Molecular Genetics

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