Description:

The Department of Biochemistry & Molecular Genetics presents:

Kai Tan, PhD
Richard & Sheila Sanford Professor
Departments of Pediatrics, Cell & Dev Biology, Genetics
Director, Center for Single Cell Biology
Children’s Hospital of Philadelphia
Perelman School of Medicine
University of Pennsylvania

Presentation:

"Progenitor cells in therapy resistance of high-risk leukemias"

Abstract:

The role of leukemic initiating cells as a therapy-resistant population in myeloid leukemia is well established. However, the existence and molecular signatures of stem/progenitor-like blasts in acute lymphoblastic leukemia have not been studied extensively. I will  discuss the identification, characterization, targeting of a pan-leukemia HSPC-like blast population associated with chemotherapy resistance and unfavorable patient outcome, using integrative analysis of single-cell multiomics, bulk RNA-Seq and clinical data.

Host: Dr Ruli Gao, Assistant Professor of Biochemistry and Molecular Genetics