When:
Thursday, February 22, 2024
10:00 AM - 11:00 AM CT
Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Linda Mekhitarian Jackson
(312) 503-5229
Group: Biochemistry & Molecular Genetics Seminar Series
Category: Lectures & Meetings
The Department of Biochemistry & Molecular Genetics presents:
Kai Tan, PhD
Richard & Sheila Sanford Professor
Departments of Pediatrics, Cell & Dev Biology, Genetics
Director, Center for Single Cell Biology
Children’s Hospital of Philadelphia
Perelman School of Medicine
University of Pennsylvania
Presentation:
"Progenitor cells in therapy resistance of high-risk leukemias"
Abstract:
The role of leukemic initiating cells as a therapy-resistant population in myeloid leukemia is well established. However, the existence and molecular signatures of stem/progenitor-like blasts in acute lymphoblastic leukemia have not been studied extensively. I will discuss the identification, characterization, targeting of a pan-leukemia HSPC-like blast population associated with chemotherapy resistance and unfavorable patient outcome, using integrative analysis of single-cell multiomics, bulk RNA-Seq and clinical data.
Host: Dr Ruli Gao, Assistant Professor of Biochemistry and Molecular Genetics