Northwestern Events Calendar


CAN Seminar Series: Dr. Nael Nadif Kasri

Headshot of Nael Nadif Kasri

When: Monday, May 20, 2024
12:00 PM - 1:00 PM CT

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Wesley Gryziak  

Group: Center for Autism and Neurodevelopment

Category: Lectures & Meetings


"Deregulated autophagy as underlying mechanism of neurodevelopmental disorders"

Neurodevelopmental disorders (NDDs) encompass a diverse array of conditions characterized by disruptions in central nervous system (CNS) development. A significant subset of NDDs, termed chromatinopathies, stem from mutations in genes responsible for epigenetic regulation, which modulate gene expression. Interestingly, a number of these chromatinopathy genes also govern the regulation of autophagy-related genes. These insights underscore the critical importance of tightly controlling the transcription of autophagy-related genes to manage autophagic activity. Autophagy, a highly conserved catabolic process, plays a pivotal role in maintaining cellular homeostasis and promoting survival by clearing cytosolic contents.. Leveraging genome-engineered and patient-derived stem cell models, we systematically investigated dysregulated autophagy as a potential shared underlying mechanism across different chromatinopathies. Our findings demonstrate that dysregulated autophagy contributes to neuronal and synaptic deficiencies observed in numerous chromatinopathies. This presents a promising avenue for advancing our understanding of disease pathology and, importantly, offers opportunities for the development of more targeted therapies for a broader spectrum of NDDs.

Prof. Dr. Nael Nadif Kasri
Department of Human Gentetics
Radboud University Medical Center

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