BMG Seminar: Michael Pacold, MD, PhD, NYU Grossman School of Medicine
When:
Thursday, September 26, 2024
10:00 AM - 11:00 AM CT
Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Linda Mekhitarian Jackson
(312) 503-5229
Group: Biochemistry & Molecular Genetics Seminar Series
Category: Lectures & Meetings
Description:
The Department of Biochemistry & Molecular Genetics presents:
Michael Pacold, MD, PhD
Assistant Professor of Radiation Oncology
NYU Grossman School of Medicine
Presentation:
"An Unexpected Journey Tracing Molecular Oxygen”
Abstract:
Oxygen-dependent reactions are required for the growth and survival of human cells. Yet, the fate of molecular oxygen in mammalian cells is incompletely understood. We have developed techniques for tracing isotopically labeled oxygen into metabolites in mammalian cells. This work has revealed the first committed step of the mammalian Coenzyme Q10 (CoQ10) headgroup synthesis pathway. The CoQ10 headgroup accepts and donates electrons, and is required for CoQ10’s role in mitochondrial electron transport and as a quencher of reactive oxygen species in biological membranes. I will discuss our work on CoQ10 headgroup synthesis and its role in brain development.
Host: Dr. Issam Ben-Shara, Associate Professor of Biochemistry and Molecular Genetics