Northwestern Events Calendar


BMG Seminar: Joseph Baur, PhD, University of Pennsylvania

When: Thursday, March 7, 2024
10:00 AM - 11:00 AM CT

Where: Simpson Querrey Biomedical Research Center, Simpson Querrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Linda Mekhitarian Jackson   (312) 503-5229

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings


The Department of Biochemistry & Molecular Genetics presents:

Joseph Baur, PhD
Professor, Institute for Diabetes, Obesity and Metabolism and Department of Physiology
Perelman School of Medicine at the University of Pennsylvania 


"NAD+ metabolism in mammals and microbes”


Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor essential to all living organisms. NAD+ levels fall with age or disease and rise with exercise or caloric restriction. Supplemental NAD+ precursors have beneficial effects on health in rodent models, renewing interest in this molecule and the enzymes that require it. Although NAD+ is present in the mitochondrial matrix and critical to the function of the organelle, the source of mitochondrial NAD+ was only recently elucidated. We identified SLC25A51 as the carrier that is primarily responsible for this activity in cultured cells. Here we show that, like in cells, SLC25A51 is important for establishing the mitochondrial NAD+ pool in vivo. Shifting NAD+ into hepatic mitochondria is sufficient to replicate the effects of supplemental NAD+ precursors on liver regeneration. Thus, the mitochondrial NAD+ pool appears to be responsible for some of the benefits of increasing whole-body NAD+. In a separate series of studies, we have used heavy isotope tracing strategies to show that the popular supplement nicotinamide riboside is metabolized by the microbiome when administered orally to mice. Further studies revealed a surprising role for the microbiome in normal NAD+ metabolism. Host-derived nicotinamide is released into the gut lumen and processed to generate microbial NAD+ as well as nicotinic acid that is reabsorbed by the host. These findings reveal a previously unappreciated cycle by which NAD+ precursors are shared between the host and microbes.

Host: Dr. Clara Peek, Assistant Professor of Biochemistry and Molecular Genetics and and Medicine (Endocrinology)

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