BEGIN:VCALENDAR
PRODID:-//planitpurple.northwestern.edu//iCalendar Event//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
CLASS:PUBLIC
BEGIN:VTIMEZONE
TZID:America/Chicago
TZURL:http://tzurl.org/zoneinfo-outlook/America/Chicago
X-LIC-LOCATION:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SEQUENCE:0
DTSTART;TZID=America/Chicago:20240315T120000
DTEND;TZID=America/Chicago:20240315T130000
DTSTAMP:20260914T124043Z
SUMMARY:CTPR Seminar Series: Dr. Tomas Nevian "Neural circuits and therapeutics for pain unpleasantness and its cognitive modulation"
UID:611056@northwestern.edu
TZID:America/Chicago
DESCRIPTION:"Neural circuits and therapeutics for pain unpleasantness and its cognitive modulation"  The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However\, the involved brain regions are not specific for pain. Thus\, how the cortex distinguishes nociception from other aversive and salient sensory stimuli remains elusive. Additionally\, the consequences of the plastic changes that induce chronic neuropathic pain on sensory processing have not been characterized properly. Using in vivo miniscope calcium imaging with cellular resolution in freely moving mice\, we studied the principles of nociceptive and sensory coProf. Dr. Thomas Nevian\, from the University of Bern\, Department of Physiologyding in the anterior cingulate cortex (ACC)\, a region essential for pain processing. We found that population activity\, not single-cell responses\, allowed discriminating noxious from other sensory stimuli\, ruling out the existence of nociception-specific neurons. Additionally\, single-cell stimulus selectivity was highly dynamic over time\, but stimulus representation at the population level remained stable. Peripheral nerve injury-induced chronic neuropathic pain led to dysfunctional encoding of sensory events by exacerbation of responses to innocuous stimuli and impairment of pattern separation and stimulus classification\, which were restored by analgesic treatment. Furthermore\, I will discuss the influence of afferent pathways to the ACC that contribute to nociceptive processing and behavioral decision-making in pain.  Prof. Dr. Thomas Nevian University of Bern Department of Physiology
LOCATION:Ward Building\, 5-230\, 303 E. Chicago Avenue\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/611056
CREATED:20240228T060000Z
STATUS:CONFIRMED
LAST-MODIFIED:20240228T060000Z
PRIORITY:0
BEGIN:VALARM
TRIGGER:-PT10M
ACTION:DISPLAY
DESCRIPTION:Reminder
END:VALARM
END:VEVENT
END:VCALENDAR