When:
Tuesday, April 30, 2024
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Seminar Title:
Inhibition of Kaposi’s Sarcoma Associated Herpesvirus microRNAs in Primary Effusion Lymphoma
Speaker: Jesus Ortega, Graduate Student, Driskill Graduate Program
Topic:
Kaposi's Sarcoma Herpesvirus (KSHV) causes several human cancers, including the non-Hodgkin’s body cavity primary effusion lymphoma (PEL). In PEL, KSHV remains latent, expressing few proteins and several viral microRNAs (miRNAs). To date, specific challenges with KSHV biology have precluded effective viral miRNA loss-of-function studies. By exploring new mechanistic insights into miRNA turnover, I achieve robust miRNA inhibition, highlighting the essentiality of a viral miRNA mimic of miR-155 in sustaining viability and proliferation of patient-derived PEL.
Host: Dr. Eva Gottwein, Associate Professor, Dept. of Microbiology-Immunology