Title: "Interpretable models to understand regulation of RNA splicing."
Abstract: Burge lab is developing fully interpretable models of RNA splicing and its regulation for improved understanding and various applications. They have developed a model of regulation from in vitro RNA binding data and splicing factor knockdown experiments called KATMAP that predicts precise patterns of activity, distinguishes direct from indirect effects, and detects cooperative activity. He will also discuss our findings that proteins of the Luc7 family recognize two distinct subclasses of 5’ splice sites, with implications leukemia, metabolic regulation and the evolution of introns.
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Christopher Burge, PhD, CSB Program Director; Professor of Biology; Extramural Member of KIICR; Associate Member of the Broad Institute, Massachusetts Institute of Technology.
Melissa Daley
Email