Description:

The Department of Biochemistry & Molecular Genetics presents:

Scott B Rothbart, PhD
Professor, Department of Epigenetics
Co-Director, NCI T32 Cancer Epigenetics Training Program
Van Andel Institute, Grand Rapids, MI

Presentation:

"Mechanisms and therapeutic targeting of chromatin modification crosstalk"

Abstract:

My lab studies basic cellular and molecular mechanisms regulating chromatin accessibility, interaction, and function. We are particularly interested in the interconnected molecular activities of proteins that write, erase, and read histone post-translational modifications (PTMs) and DNA methylation, and we seek to understand roles for these chromatin modifications in the regulation of transcription, DNA replication, chromatin organization, and the preservation of cell identity. Our studies are facilitated by the development and improvement of tools and technologies for the field. As chromatin modifiers and associated proteins are frequently mutated and dysregulated in human diseases, most notably cancer, our studies are also revealing pathological mechanisms associated with chromatin dysregulation, identifying new targets for drug discovery, and providing mechanistic rationale for multi-targeted therapeutic approaches to improve patient outcomes. Direct translation of our findings to clinical trials is facilitated by an Epigenetic Therapies NCI SPORE grant (the second discipline-based SPORE awarded) and the Van Andel Institute-Stand Up to Cancer Epigenetics Dream Team, where I participate as a Basic Science Investigator.

Host: Dr. Shannon Lauberth, Associate Professor of Biochemistry and Molecular Genetics