Pharmacology Faculty Candidate Seminar | Tao Che PhD "Structural basis of GPCR activation and signaling"

Title: "Structural basis of GPCR activation and signaling."
Abstract: G protein-coupled receptors (GPCRs) are a class of seven-transmembrane proteins that sense external stimuli of the neurons and cells. They are the largest druggable targets, involved in over 35% of marketed drugs. Understanding their interactions with drugs and subsequent cellular signaling mechanisms can help mitigate drug side effects. Here, we focus on the opioid receptor family, addressing three topics: first, how opioids interact with opioid receptors at the molecular level; second, how receptor activation initiates different downstream signaling at the cellular level; and third, how this information can inform new drug design.

Tao Che, PhD, Assistant Professor, Center for Clinical Pharmacology, Department of Anesthesiology, Washington University in St. Louis
 

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