Northwestern Events Calendar

Oct
10
2024

"Spying on Neuromodulator Dynamics In Vivo by constructing GRAB Sensors" | Yulong Li, Ph.D

When: Thursday, October 10, 2024
12:00 PM - 1:00 PM CT

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Jenna Ward   (815) 529-6182

Group: Department of Neuroscience Seminars

Category: Lectures & Meetings

Description:

The Department of Neuroscience Welcomes Dr. Yulong Li.

Principal Investigator

Fluorescencent Probe, Neuroimaging, Synaptic Transmission, Signal Transduction, Neurological Diseases.

The human brain consists of billions of neurons, most of which communicate with each other by releasing different kinds of neuromodulators through chemical synapses, and therefore is able to control different physiological functions like perception, motion, learning and memory. To dissect the mechanism underlying how brain take part in different physiological functions and pathological conditions, it's important to monitor the dynamics of neuromodulators in vivo. In the past few years, we and others have developed a series of multi-color GPCR-activation‒based (GRAB) sensors for monitoring extracellular neuromodulator dynamics with high sensitivity, specificity, and spatial-temporal resolution in living animals. In this report, I will share our recent progress in developing sensors for monitoring monoamines, nucleotides, neurolipids and neuropeptides. With these GRAB sensors, we have monitored the dynamics of neuromodulators in mice in a wide range of physiological processes (sleep-wake cycle, motion, etc.) and pathological conditions (epilepsy, etc.).

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