M-I Seminar Series: Activation and Evasion of the FEAR Pathway by DNA and RNA Viruses

Title: Activation and Evasion of the FEAR Pathway by DNA and RNA Viruses

Topic:

We recently identified the FACT-ETS-1 Antiviral Response (FEAR) pathway as an innate immune response that restricts diverse viruses. I will discuss the discovery of the FEAR pathway, its regulation, and how DNA and RNA viruses use distinct mechanisms to antagonize this response. Collectively, our work reveals a new interferon-independent antiviral immunity pathway as well as unappreciated immune evasion strategies employed by viral pathogens.

Speaker: Don Gammon, PhD, Assistant Professor, UT Southwestern

Host: Derek Walsh, PhD, Professor, Dept. of Microbiology-Immunology

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