M-I Seminar Series: The Role of Universal Stress Proteins in Methicillin-Resistant Staphylococcus aureus: Szu-Yu Kuan, Driscoll Graduate Program

Title:  The Role of Universal Stress Proteins in Methicillin-Resistant Staphylococcus aureus

Speaker: Szu-Yu Kuan, Driscoll Graduate Program, Lab of Dr. M.-N. Frances Yap

Topic:

Universal stress proteins (Usps) are widely distributed across bacteria, bacteriophages, archaea, metazoans, and plants but are absent in humans. The precise biochemical activities of these proteins remain poorly understood. The opportunistic human pathogen Staphylococcus aureus USA300 carries four annotated usp genes. Among them, I found that one, usp1656, is constitutively expressed throughout all growth phases. The usp1656 mutant exhibits extreme sensitivity to superoxide and shows reduced virulence. I will discuss the role and biochemical properties of Usp1656 in staphylococcal stress adaptation and nucleotide signaling.

Host: M.-N. Frances Yap, Associate Professor, Dept. of Microbiology-Immunology

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