Description:

Title:  Elucidating the role of Lag3 as a regulator of Treg metabolism and function

Topic: Lymphocyte activation gene-3 (Lag3) is an inhibitory co-receptor highly expressed on exhausted T cells. Targeting Lag3 has emerged as a promising strategy to reinvigorate anti-tumor immunity. While the primary function of Lag3 is to inhibit conventional T cell activation, its role in Foxp3+ regulatory T cells (Tregs) remains largely unclear. In this presentation, I will highlight our lab’s recent findings that Lag3 supports Treg function by modulating metabolism. I will also discuss our ongoing study into a previously unexplored conserved intracellular motif of Lag3, which is crucial for Lag3-dependent Treg function.

Speaker: Ghia Kim, Driscoll Graduate Program, Lab of Bookie Min

Host: Bookie Min, PhD, Professor, Dept. of Microbiology-Immunology