Description:

Title: Flying Under the Radar: How Salmonella Evolves to Persist in Humans

Topic:

Many clinically important bacterial pathogens, including Salmonella enterica, are able to establish persistent infections in humans. These persistent bacteria can evade the host immune system and killing by antibiotics, and provide a reservoir of disease for infection of healthy individuals. From the largest retrospective study of Salmonella to date, I collected and whole genome sequenced all S. enterica isolates obtained from patients presenting with persistent salmonellosis in order to determine within host evolution of this important bacterial pathogen. 

Speaker: Alexandra  Grote, MD, PhD, Dept. of Medicine, Infectious Diseases Division, Northwestern University

Host: Alan Hauser, MD, PhD, Professor, Dept. of Microbiology-Immunology