Description:

The Department of Biochemistry & Molecular Genetics presents:

Qin Yan, PhD
Professor of Pathology
Co-Leader, Genomics, Genetics and Epigenetics Research Program, Yale Cancer Center; Director, Center for Epigenetics and Biomarkers, Pathology; Scientific Co-Director, Center for Breast Cancer, Yale Cancer Center
Yale School of Medicine

Presentation:

"Epigenetic Control of Cancer Metastasis and Immune Evasion”

Abstract:

Epigenetic dysregulation often leads to cancer and other human diseases.  Tumors exploit epigenetic mechanisms to evade immune surveillance and metastasize to distant organs.  We recently identified and characterized multiple epigenetic and epitranscriptomic regulators of immune evasion and metastasis, including KDM5 histone demethylases and NAT10 acetyltransferase. The mechanisms of action by these regulators and therapeutic implications will be discussed.

Host: Dr. Lu Wang, Assistant Professor of Biochemistry and Molecular Genetics