Description:

The Department of Biochemistry & Molecular Genetics presents:

Leng Han, PhD
David Brown Chair Professor
Brown Center for Immunotherapy, Department of Biostatistics and Health Data Science
Indiana University School of Medicine

Presentation:

"Harnessing big data for precision medicine”

Abstract:

Despite advancements in treatment options for cancer, a majority of cancer types continue to lack fully characterized and effective targeted therapies to improve disease diagnostics, prognoses, and patient survival outcomes. Therefore, there is an urgent need to gain a more comprehensive understanding of the molecular basis of diseases and develop novel prognostic and therapeutic strategies. Our lab utilizes cutting-edge techniques in systems biology to understand the molecular mechanisms of complex diseases. We conducted a series of pan-cancer analyses to provide clinical insights into cancer therapy, including RNA targeted therapy (Journal of the National Cancer Institute, 2018; Genome Medicine, 2019a; Genome Medicine, 2019b; Nature Communications, 2019; Cancer Research, 2022), chronotherapy (Cell Systems, 2018), hypoxia-targeted therapy (Nature Metabolism, 2019), target therapy (Genome Medicine, 2020a), autophagy-targeted therapy (Nature Communications, 2022), and immunotherapy (Nature Immunology, 2019; Nature Communications, 2020a; Nature Communications, 2020b; Genome Medicine, 2020b; Advanced Science, 2020; Journal of the National Cancer Institute, 2021; Cancer Cell, 2021; The Innovation, 2021; Journal for Immunotherapy of Cancer, 2022; Nature Reviews Clinical Oncology, 2022; Cell Metabolism, 2023; The Innovation, 2023; Nature Reviews Clinical Oncology, 2023). These studies shed light on future clinical considerations for the development of innovative therapies for cancer types currently lacking effective treatment options. We will further develop highly innovative prognostic and therapeutic strategies with the potential to produce a major impact on biomedical research. 

Host: Dr. Ruli Gao, Assistant Professor of Biochemistry and Molecular Genetics