When:
Tuesday, December 3, 2024
12:15 PM - 1:15 PM CT
Where: Robert H Lurie Medical Research Center, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: Vibrio cholerae Inflammation Driven Intestinal Colonization
Speaker: Jori Orion MIlls, DGP Graduate Student, Satchell Lab
Topic:
Vibrio cholerae is the bacterium responsible for the disease cholera. The establishment and persistence of V. cholerae infection are assisted by the Multifunctional-Autoprocessing Repeats-in-Toxin (MARTX). The MARTX toxin actin crosslinking domain (ACD) triggers proinflammatory host signaling. I have explored a conserved cellular response to actin damage and implicating reactive oxygen species and IRE1 and this host response promotes colonization.
Host:
Karla Satchell, PhD, Professor, Department of Microbiology-Immunology