Description:

Speaker: Stephanie Dodson (Colby College)

Title: Curvature dependent onset of oscillations in excitable tissue 

Zoom Link: https://illinois.zoom.us/j/82616248519?pwd=CAR0v0aaIpTnIVwxJDa59wFvusobot.1

Abstract: In cardiac tissue, the sinoatrial node (SAN) is responsible for initiating the periodic electrical pulses underlying heart beats. However, other regions of local heterogeneous tissue can act as rogue pacemakers and produce ectopic oscillations in neighboring tissue that compete with the natural pacemaking of the SAN and cause potentially life-threatening arrhythmias. Thus, it is important to understand the physiological conditions that enable the SAN to robustly act as the cardiac pacemaker and for local depolarized regions of tissue to form pathological rhythms. It is well known that small heterogeneities (sources) should not be able to easily activate a large area of excitable tissue (sink). On a local level, this source-sink balance implies that positive curvature of a pacemaking region reduces the ability to drive the neighboring tissue. However, while numerous studies provide evidence that supports the source-sink balance relationship in which high curvature deters oscillations, other studies have shown that for some depolarized heterogeneities, oscillations tend to emerge from corners and other areas of high curvature. In this research, we use an idealized two-domain reaction-diffusion system and corresponding two-cell model to bridge the gap between these seemingly opposing viewpoints. In doing so, we identify the conditions for which curvature of a pacemaking region promotes or obstructs the production of oscillations in the neighboring tissue. This work is a joint collaboration with Tim Lewis (UC Davis) and Emily Meyer (University of Colorado Anschutz Medical Campus).