Description:

Neuronal circuits, the biological units underlying cognitive processes and behaviors, are formed by an optimal number of excitatory and inhibitory neurons connected in specific ways. Several studies suggested the existence of a deterministic program set up at birth and determining interneurons to connect to excitatory neurons born at a similar time. Recent work, including mine, revealed that interneuron genesis and migration are stochastic processes, challenging the concept that, since birth, interneurons “know” where to go and whom to connect to. The emerging question is: which rules are then interneurons following, to organize into circuits according to the schedule of neurogenesis? A possibility is that stochasticity during migration maximizes the chance of some interneurons capturing extracellular information relevant for circuit integration. The period of migration promotes the encounter and interaction of interneurons with other cell populations, creating a complex spatial context. Specific interactions with the microenvironment could instruct interneurons for connectivity. How the cellular environment influences the connectivity choices of interneurons remains unknown. Understanding how neurons select partners to form circuits is a matter of great interest since developmental and some psychiatric diseases have an early onset, while connectivity decisions are made. This knowledge is also important for elucidating when, where, and how to intervene to repair disrupted circuits.

Carla Gomes da Silva, Assistant Professor, UMC, Utrecht, Netherlands

Host: Adilson Motter