Description:

The Department of Biochemistry & Molecular Genetics presents:

Eftychia (Effie) Apostolou, PhD
Associate Professor of Molecular Biology in Medicine
Department of Medicine and Meyer Cancer Center
Weill Cornell Medical College

Presentation: 

"Building, predicting and targeting 3D regulatory networks in development and cancer"

Abstract:

My group focuses on the study of 3D chromatin organization and its interplay with transcription during cell fate transitions, such as reprogramming and differentiation. This talk will focus on our efforts to construct cell-type specific 3D regulatory networks in order to identify central 3D regulatory hubs, and to model and predict transcriptional behaviors in early development and in Glioblastoma. I will also present unpublished findings regarding a physiological, transient acquisition of a plastic state in terminally differentiated Germinal Center B cells during adaptive immune response.

Host: Dr. Feng Yue, Professor, Biochemistry and Molecular Genetics, Pathology