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DTSTART;TZID=America/Chicago:20251106T100000
DTEND;TZID=America/Chicago:20251106T110000
DTSTAMP:20260610T222943Z
SUMMARY:BMG Seminar: Karlene A. Cimprich\, PhD\, Stanford Medicine
UID:633705@northwestern.edu
TZID:America/Chicago
DESCRIPTION:The Department of Biochemistry & Molecular Genetics presents:  Karlene A. Cimprich\, PhD Professor and Vice-Chair of Chemical and Systems Biology and\, by courtesy\, of Biochemistry Stanford Cancer Institute Leader\, Genome Stability Research Stanford University\, School of Medicine  Presentation:   RNA Meets DNA: Dangerous Encounters in the Genome  Abstract:  R-loops are three-stranded nucleic acid structures that form co-transcriptionally and which are comprised of an RNA-DNA hybrid and a displaced strand of ssDNA. Although R-loops have important functions in cells\, their aberrant formation can also lead to genome stability causing replication stress and double-strand break formation. We showed that a surprising consequence of unscheduled R-loop formation is the release of RNA-DNA hybrid fragments into the cell cytoplasm and sensing of these hybrids by innate immune receptors. I will describe our recent studies demonstrating how these pathological hybrids arise in different contexts and the features that cause them to threaten genome stability. Our findings reveal two distinct mechanisms by which cytoplasmic RNA-DNA hybrids accumulate and serve to link transcriptional dysregulation and innate immune activation.  Host: Dr. Daniel Foltz\, Professor\, Biochemistry and Molecular Genetics  Refreshments will be served.
LOCATION:Robert H Lurie Medical Research Center\, Searle Seminar Room\, 303 E. Superior\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/633705
CREATED:20220725T050000Z
STATUS:CONFIRMED
LAST-MODIFIED:20251002T210628Z
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DESCRIPTION:Reminder
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