Description:

Title: Beyond ATP: Mitochondrial Signaling as a Master Regulator of Treg Function

Description: Regulatory T cells (Tregs) are essential for maintaining immune tolerance and preventing autoimmunity, yet their suppressive activity within tumor microenvironments enables cancer immune evasion. While mitochondrial metabolism has long been recognized as a defining feature of Tregs, the causal mechanisms linking specific metabolic pathways to suppressive function have remained unclear. Our work reveals that distinct mitochondrial signals—including redox balance and TCA cycle metabolites—independently control different aspects of Treg regulatory function, providing new insights into how cellular metabolism dictates immunologic outcomes and offering potential strategies to selectively modulate Treg activity in disease.