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DTSTART;TZID=America/Chicago:20260522T100000
DTEND;TZID=America/Chicago:20260522T110000
DTSTAMP:20260514T040839Z
SUMMARY:Yi Gu (NIH): NITMB Seminar Series
UID:637608@northwestern.edu
TZID:America/Chicago
DESCRIPTION:Title: Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells  Abstract: Animals construct internal “cognitive maps” of the world during navigation in spatial and non-spatial domains\, with grid cells in the medial entorhinal cortex (MEC) playing a key role. This requires associating internal position estimates with external cues to reduce spatial uncertainty over time. However\, how grid cell representations evolve in novel spaces to support map formation is unclear. To address this question\, we longitudinally imaged calcium dynamics of grid cells over 10 days as mice learn operant tasks in novel virtual linear tracks. We observe that spatial tuning of grid cells is present immediately in novel tracks but evolves as a significant fraction of spatial fields shift backward on a run-by-run basis\, within and across days. Backward shifts are more prevalent and persistent in successful learners. The fields gradually stabilize across days\, anchored by landmarks\, suggesting slow plasticity. The backward shifts partially reset daily\, reflecting a slower consolidation timescale. While individual fields of a cell shift differentially\, co-active fields of co-modular grid cells shift together\, indicating their coupled dynamics on the same two-dimensional torus. Spatial learning leads to systematic changes and stabilization of their population phase trajectory\, including lateral shift\, rotation\, and phase resets at landmarks\, forming a landmark-fragmented representation for the environment. Next\, we build an entorhinal-hippocampal model that provides a mechanistic explanation of the diverse phenomena - grid field shifts\, increasing fidelity\, and fragmentation of the spatial map - and predicts slow Hebbian plasticity in the hippocampus-to-entorhinal pathway. Supporting this\, electrophysiology demonstrates that learning-performance-correlated weakening of local inhibition facilitates potentiation of indirect hippocampal inputs to superficial MEC. Together\, our study provides multifaceted evidence of slow hippocampus-to-MEC plasticity\, elucidating the formation of stable and fragmented cognitive maps that combine internal and cue-driven positional estimates in rich environments during learning. This mechanism may extend to broader memory processes involving this circuit.  Yi Gu is an Investigator in the Spatial Navigation and Memory Unit at the National Institutes of Health's National Institute of Neurological Disorders and Stroke. Gu's research is focused on the neural basis of spatial navigation and memory\, with the ultimate goal to uncover the fundamental principle of spatial cognition and the cause of related neurological disorders. She is primarily interested in the medial entorhinal cortex (MEC)\, which plays a key role in spatial representation and episodic memory. The MEC is a part of medial temporal lobe and serves as the main gateway between the hippocampal formation and the neocortex. Many functional cell types\, including grid cells\, head-direction cells\, border cells\, speed cells\, and object vector cells\, have been discovered in the MEC and their activity patterns potentially represent spatial and self-motion information during navigation. Dysfunction of the MEC is closely associated with Alzheimer's Disease (AD)\, the most common form of dementia. AD patients generally exhibit severe loss of episodic memory and have difficulty in spatial navigation.  The NSF-Simons National Institute for Theory and Mathematics in Biology Seminar Series aims to bring together a mix of mathematicians and biologists to foster discussion and collaboration between the two fields. The seminar series will take place on Fridays from 10am - 11am at the NITMB in the John Hancock Center in downtown Chicago. There will be both an in-person and virtual component.\n\nMore Info: https://www.nitmb.org/nitmb-seminar-series
LOCATION:Suite 3500\, 875 N Michigan Ave\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://www.nitmb.org/nitmb-seminar-series
CREATED:20260102T060000Z
STATUS:CONFIRMED
LAST-MODIFIED:20260422T135427Z
PRIORITY:0
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