BEGIN:VCALENDAR
PRODID:-//planitpurple.northwestern.edu//iCalendar Event//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
CLASS:PUBLIC
BEGIN:VTIMEZONE
TZID:America/Chicago
TZURL:http://tzurl.org/zoneinfo-outlook/America/Chicago
X-LIC-LOCATION:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SEQUENCE:0
DTSTART;TZID=America/Chicago:20260312T140000
DTEND;TZID=America/Chicago:20260312T150000
DTSTAMP:20260127T000000
SUMMARY:CAN Seminar Series: Advancing Clinical Translational Research into Profound Autism. 
UID:638530@northwestern.edu
TZID:America/Chicago
DESCRIPTION:Matthew W. State MD\, PhD Oberndorf Family Distinguished Professor and Chair  Department of Psychiatry and Behavioral Sciences  Director\, Langley Porter Psychiatric Institute Weill Institute for Neurosciences  University of California\, San Francisco   More than a decade of progress in genetics and genomics and rapid advances in human neuroscience are driving clinical translation to an inflection point for those most severely affected with autism spectrum disorders (ASD). Individuals with ASD\, minimal or absent language\, co-occurring intellectual disability\, and the requirement for 24-hour care are increasingly being considered as a distinctive clinical cohort — and are serving as the basis for a proposed new formal diagnostic category of Profound Autism. These individuals\, who collectively constitute about a quarter of the ASD clinical population\, share an increased rate of rare\, large-effect\, often de novo genetic mutations\, pointing to specific high-confidence risk genes contributing to their clinical syndrome(s).  This presentation will provide an update on the current understanding of the genetic contribution to profound ASD\, describe how the discovery of large-effect risk genes is creating distinctive opportunities for therapeutic development\, and delineate some of the major ongoing challenges to leveraging these advances to drive transformation in the clinic. The talk with also describe the roadmap for a new philanthropic initiative aimed at creating an international clinical-translational ecosystem supporting rapid progress in assessing and caring for those most severely impaired on the autism spectrum. \n\nWebcast Link: https://northwestern.zoom.us/j/95605834128
LOCATION:Simpson Querrey Biomedical Research Center\, SQBRC Simpson-Querrey Auditorium\, 303 E. Superior Street\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:
CREATED:20260127T000000
STATUS:CONFIRMED
LAST-MODIFIED:20260302T101547
PRIORITY:0
BEGIN:VALARM
TRIGGER:-PT10M
ACTION:DISPLAY
DESCRIPTION:Reminder
END:VALARM
END:VEVENT
END:VCALENDAR