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DTSTART;TZID=America/Chicago:20260316T150000
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SUMMARY:Department of Pharmacology Works in Progress: Caleb Embree\, PhD & Vernon Kennedy
UID:639192@northwestern.edu
TZID:America/Chicago
DESCRIPTION:Department of Pharmacology Works in Progress:   Speaker: Caleb Embree\, PhD Postdoctoral fellow in the lab of Katherine Borden\, PhD  Title: "Mismatched SOCCS: Nuclear eIF4E and NCBP2 govern distinct fates for 1000s of mRNAs uncovering an unexpected regulatory point in gene expression"     Abstact: Protein coding transcripts possess 5’ m7G “cap” which are recognized by cap-binding proteins that shepherd mRNAs through the major mRNA processing steps\, RNA export and translation. Both the cap binding complex (CBC) made of the NCBP2/NCBP1 heterodimer and eIF4E are present in the nucleus and play a role in mRNA processing. To determine if these two cap-chaperones are functionally redundant we overexpressed NCBP2 and eIF4E in U2OS cells and examined how they affected pre-mRNA splicing. We found that the two proteins regulate distinct alternative splicing programs\, suggesting a novel regulatory mechanism we have named specification of cap-chaperones (SOCCS)\, whereby cap-chaperones regulate the processing of specific subsets of mRNA.  ---------------------------------------------------------------------  Speaker: Vernon Kennedy MD-PhD Candidate in the lab of Murali Prakriya\, PhD  Title: "Orai1-mediated SOCE in the Choroid Plexus and its Role in Neuroinflammation"   Abstract: Calcium (Ca2+) is a key second messenger regulating cellular processes\, including vesicular exocytosis\, gene expression\, and cell homeostasis. Store-operated Ca2+ entry (SOCE)\, mediated by Orai1 channels\, is a major Ca2+ entry pathway in most cells. In the brain\, Orai1 is highly expressed in the choroid plexus (CP)\, which produces cerebrospinal fluid\, maintains the blood-CSF barrier\, and plays a central role in CNS immune surveillance. Using pharmacological and genetic approaches with calcium imaging\, I demonstrate that Orai1 is essential for SOCE and serotonin-induced Ca2+ signals in the CP epithelium\, and that it regulates proinflammatory gene expression and barrier remodeling\, identifying Orai1 as a key mediator linking serotonin signaling to CP immune function and neuroinflammation.
LOCATION:Ward Building\, 5-230\, 303 E. Chicago Avenue\, Chicago\, IL 60611
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CREATED:20260220T000000
STATUS:CONFIRMED
LAST-MODIFIED:20260303T101654
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