BEGIN:VCALENDAR
PRODID:-//planitpurple.northwestern.edu//iCalendar Event//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
CLASS:PUBLIC
BEGIN:VTIMEZONE
TZID:America/Chicago
TZURL:http://tzurl.org/zoneinfo-outlook/America/Chicago
X-LIC-LOCATION:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SEQUENCE:0
DTSTART;TZID=America/Chicago:20260416T100000
DTEND;TZID=America/Chicago:20260416T110000
DTSTAMP:20260411T104919Z
SUMMARY:BMG Seminar: Zhiping Weng\, PhD
UID:641312@northwestern.edu
TZID:America/Chicago
DESCRIPTION:The Department of Biochemistry & Molecular Genetics presents:  Zhiping Weng\, PhD  Chair of Department of Genomics and Computational Biology  Professor of Biochemistry and Molecular Biotechnology   University of Massachusetts Chan Medical School  Presentation:   An Expanded Registry of Candidate Cis-Regulatory Elements  Abstract:   Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression1. Previously\, the ENCODE consortium mapped biochemical signals across hundreds of cell types and tissues and integrated these data to develop a registry containing 0.9 million human and 300\,000 mouse candidate cis-regulatory elements (cCREs) annotated with potential functions2. Here we have expanded the registry to include 2.37 million human and 967\,000 mouse cCREs\, leveraging new ENCODE datasets and enhanced computational methods. This expanded registry covers hundreds of unique cell and tissue types\, providing a comprehensive understanding of gene regulation. Functional characterization data from assays such as STARR-seq3\, massively parallel reporter assay4\, CRISPR perturbation5\,6 and transgenic mouse assays7 have profiled more than 90% of human cCREs\, revealing complex regulatory functions. We identified thousands of novel silencer cCREs and demonstrated their dual enhancer and silencer roles in different cellular contexts. Integrating the registry with other ENCODE annotations facilitates genetic variation interpretation and trait-associated gene identification\, exemplified by the identification of KLF1 as a novel causal gene for red blood cell traits. This expanded registry is a valuable resource for studying the regulatory genome and its impact on health and disease.   Host: Feng Yue\, PhD   Refreshments will be served.            
LOCATION:Simpson Querrey Biomedical Research Center\, SQBRC Auditorium\, 303 E. Superior Street\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/641312
CREATED:20260401T050000Z
STATUS:CONFIRMED
LAST-MODIFIED:20260406T202626Z
PRIORITY:0
BEGIN:VALARM
TRIGGER:-PT10M
ACTION:DISPLAY
DESCRIPTION:Reminder
END:VALARM
END:VEVENT
END:VCALENDAR